Recombinant PIM1 抗体
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北京 101111
Quick Overview for Recombinant PIM1 抗体 (ABIN7828461)
抗原
See all PIM1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Pim-1 Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-Pim-1 Oncogene (PIM1) (AA 122-261) antibody
PIM1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Pim-1 Oncogene (PIM1) antibodyPIM1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Pim-1 Oncogene (PIM1) (AA 1-100) antibodyPIM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C10 unconjugated
anti-Pim-1 Oncogene (PIM1) antibodyPIM1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1410 unconjugated Recombinant Antibody
anti-Pim-1 Oncogene (PIM1) (AA 1-100) antibodyPIM1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C9 unconjugated
anti-Pim-1 Oncogene (PIM1) (AA 1-313) antibodyPIM1 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-Pim-1 Oncogene (PIM1) (AA 129-268) antibodyPIM1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Pim-1 Oncogene (PIM1) (AA 25-86) antibodyPIM1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Pim-1 Oncogene (PIM1) (AA 1-314) antibodyPIM1 适用: 人 IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-Pim-1 Oncogene (PIM1) (AA 1-314) antibodyPIM1 适用: 人 IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 6A2 unconjugated
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应用备注
- WB 1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- PIM1 (Pim-1 Oncogene (PIM1))
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别名
- Pim-1
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背景
- PIM,PIM1,Oncogene PIM 1,Oncogene PIM1,PIM 1,Pim 1 kinase,pim 1 kinase 44 kDa isoform,Pim 1 oncogene,pim 1 oncogene (proviral integration site 1),pim1 kinase 44 kDa isoform,Pim2,PIM3,Proto oncogene serine/threonine protein kinase Pim 1,Proto-oncogene serine/threonine-protein kinase Pim-1,Proviral integration site 1,Proviral integration site 2,Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases. Pim-1, a serine/threonine kinase highly expressed in hematopoietic cells, plays a critical role in the transduction of mitogenic signals and is rapidly induced by a variety of growth factors and cytokines. Pim-1 cooperates with c-Myc in lymphoid cell transformation and protects cells from growth factor withdrawal and genotoxic stress-induced apoptosis. Pim-1 also enhances the transcriptional activity of c-Myb through direct phosphorylation within the c-Myb DNA binding domain as well as phosphorylation of the transcriptional coactivator p100. Hypermutations of the Pim-1 gene are found in B-cell diffuse large cell lymphomas. Phosphorylation of Pim-1 at Tyr218 by Etk occurs following IL-6 stimulation and correlates with an increase in Pim-1 activity. Various Pim substrates have been identified, Bad is phosphorylated by both Pim-1 and Pim-2 at Ser112 and this phosphorylation reverses Bad-induced cell apoptosis.The corresponding pim-1 gene encodes a pair of proteins through use of different translation initiation sites. Both larger 44 kDa (Pim-1L) and smaller 33 kDa (Pim-1S) proteins are active kinases, but differ in stability. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 36 kDa
Observed MW: 33, 34 kDa The actual band is not consistent with the expectation.
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UniProt
- P11309
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途径
- Glycosaminoglycan Metabolic Process
抗原
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