Recombinant MPHOSPH8 抗体
The 兔 单克隆 anti-MPHOSPH8 antibody (Clone A305) (ABIN7828368) specifically detects MPHOSPH8 in WB.
The antibody is reactive with 小鼠 samples.
产品编号 ABIN7828368
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant MPHOSPH8 抗体 (ABIN7828368)
抗原
See all MPHOSPH8 抗体
MPHOSPH8
(M-Phase phosphoprotein 8 (MPHOSPH8))
抗体类型
Recombinant Antibody
适用
小鼠
宿主
兔
克隆类型
单克隆
标记
This MPHOSPH8 antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
A305
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原理
- Recombinant MPP8 Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human MPP8 fragment
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亚型
- IgG, kappa
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anti-M-Phase phosphoprotein 8 (MPHOSPH8) (AA 1-259) antibody
MPHOSPH8 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))
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别名
- MPP8
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背景
- MPP,Mphosph,MPP8,MPHOSPH8,Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 110 kDa
Observed MW: 125 kDa The actual band is not consistent with the expectation.
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UniProt
- Q99549
抗原
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