Recombinant ELANE 抗体
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北京 101111
Quick Overview for Recombinant ELANE 抗体 (ABIN7828171)
抗原
See all ELANE 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Neutrophil Elastase Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human Neutrophil Elastase fragment
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亚型
- IgG, kappa
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应用备注
- WB 1:1000-1:5000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- ELANE (Elastase, Neutrophil Expressed (ELANE))
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别名
- Neutrophil Elastase
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背景
- SCN,ELA,Elastase,ELANE,ELA2,GE,HLE,HNE,NE,PMN-E,SCN1,Elastase-2,Medullasin,Neutrophil elastase,Bone marrow serine protease,Human leukocyte elastase,PMN elastase,Elastase 2,Elastase 2 neutrophil,Elastase neutrophil expressed,ELNE,Granulocyte derived elastase,Leukocyte elastase,Neutrophil expressed,PMN E,Polymorphonuclear elastase,Neutrophil Elastase is hematopoietic serine protease that belongs to the chymotrypsin superfamily and plays a critical role in the innate immune function of mature neutrophils and monocytes. Neutrophil elastase is actively synthesized as an inactive zymogen in myelocytic precursor cells of the bone marrow, which then undergoes activation by limited proteolysis and sorting to primary (azurophil) storage granules of mature neutrophil granulocytes for regulated release. Research studies have shown that neutrophils play a significant role in mediating the inflammatory response through the release of neutrophil elastase, which activates pro-inflammatory cytokines and degrades components of the extracellular matrix and Gram-negative bacteria. Mutations in the gene encoding neutrophil elastase, ELA2, have been implicated in hematological diseases such as cyclic and severe congenital neutropenia, which is characterized by defects in promyelocyte maturation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 29 kDa
Observed MW: 29 kDa
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UniProt
- P08246
抗原
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