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Recombinant Cyclin D1 抗体 (pThr286)

The 兔 单克隆 anti-Cyclin D1 antibody is suitable to detect Cyclin D1 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC 和 FACS.
产品编号 ABIN7828139
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Recombinant Cyclin D1 抗体 (pThr286) (ABIN7828139)

抗原

See all Cyclin D1 (CCND1) 抗体
Cyclin D1 (CCND1)

抗体类型

Recombinant Antibody

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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单克隆

标记

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This Cyclin D1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

克隆位点

A202
  • 抗原表位

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    pThr286

    原理

    Recombinant Phospho-Cyclin D1 (Thr286) Monoclonal Antibody

    纯化方法

    Protein A purified

    免疫原

    Recombinant human Phospho-Cyclin D1 (Thr286) fragment

    亚型

    IgG, kappa
  • 应用备注

    WB 1:500-1:2000,IHC 1:50-1:100,FCM 1:50

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

    有效期

    12 months
  • 抗原

    Cyclin D1 (CCND1)

    别名

    Cyclin D1

    背景

    Cyl,PRAD,U21B,CCND,B cell leukemia,G1/S specific cyclin D,Cyclin D,BCL,BCL1,D11S287E,PRAD1,U21B31,CCND1,Cyclin D1,B cell leukemia 1,BCL 1,Cd1,Cyl 1,G1/S specific cyclin D1,BCL1,D11S287E,PRAD1,U21B31,CCND1,Cyclin D1,cyclin D1,Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

    分子量

    Calculated MW: 34 kDa

    Observed MW: 34 kDa

    UniProt

    P24385

    途径

    PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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