Recombinant Clusterin 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant Clusterin 抗体 (ABIN7828120)
抗原
See all Clusterin (CLU) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Recombinant Clusterin beta Chain Monoclonal Antibody
-
纯化方法
- Protein A purified
-
免疫原
- Recombinant human Clusterin beta Chain fragment
-
亚型
- IgG, kappa
-
-
-
-
应用备注
- WB 1:500-1:1000
-
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
-
有效期
- 12 months
-
-
- Clusterin (CLU)
-
别名
- Clusterin beta Chain
-
背景
- KUB,AAG,Ku70-binding protein,Sulfated glycoprotein,Complement-associated protein SP,Testosterone-repressed prostate message,NA1/NA,SGP,CLU,AAG4,APO-J,APOJ,CLI,CLU1,CLU2,KUB1,NA1/NA2,SGP-2,SGP2,SP-40,TRPM-2,TRPM2,clusterin,CLUS,Aging-associated gene 4 protein,Apolipoprotein J,Complement cytolysis inhibitor,Complement-associated protein SP-40,Ku70-binding protein 1,Sulfated glycoprotein2,Testosterone-repressed prostate message 2,Complement cytolysis inhibitor a chain,Clusterin alpha chain,Complement cytolysis inhibitor b chain,APOJ CLI,Sulfated glycoprotein 2,Clusterin (CLU) also named as apolipoprotein J, is a multifunctional glycoprotein that is expressed ubiquitously in most tissues. Clusterin functions as a secreted chaperone protein that interacts with and stabilizes stress-induced proteins to prevent their precipitation. Research studies show that clusterin plays a protective role in Alzheimer's disease by sequestering amyloid β (1-40) peptides to form long-lived, stable complexes, which prevents amyloid fibril formation.In addition to the secreted protein, several intracellular isoforms are localized to the nucleus, mitochondria, cytoplasm and ER. The subcellular distribution of these multiple isoforms leads to the diversity of clusterin functions. Additional studies report that clusterin is involved in membrane recycling, cell adhesion, cell proliferation, apoptosis, and tumor survival. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
-
分子量
-
Calculated MW: 52 kDa
Observed MW: 35 kDa The actual band is not consistent with the expectation.
-
UniProt
- P10909
-
途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
-