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Cyclin D2 抗体 (AA 161-288) (FITC)

This anti-Cyclin D2 antibody is a 兔 多克隆 antibody detecting Cyclin D2 in WB, FACS, IF (cc) 和 IF (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN738373
发货至: 中国

Quick Overview for Cyclin D2 抗体 (AA 161-288) (FITC) (ABIN738373)

抗原

See all Cyclin D2 (CCND2) 抗体
Cyclin D2 (CCND2)

适用

人, 小鼠, 大鼠

宿主

  • 68
  • 33

克隆类型

  • 71
  • 30
多克隆

标记

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This Cyclin D2 antibody is conjugated to FITC

应用范围

  • 68
  • 38
  • 17
  • 15
  • 13
  • 12
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  • 8
  • 4
  • 2
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Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 15
    • 12
    • 10
    • 7
    • 7
    • 5
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    • 2
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    • 1
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    • 1
    AA 161-288

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Cyclin D2

    亚型

    IgG
  • 应用备注

    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    Cyclin D2 (CCND2)

    别名

    Cyclin D2

    背景

    Synonyms: MPPH3, KIAK2, G1/S-specific cyclin-D2, CCND2

    Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

    基因ID

    894

    UniProt

    P30279

    途径

    Cell Division Cycle, Mitotic G1-G1/S Phases
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