SSTR2 抗体 (AA 211-320)
Quick Overview for SSTR2 抗体 (AA 211-320) (ABIN738216)
抗原
See all SSTR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 211-320
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交叉反应
- 人, 小鼠
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预测反应
- Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human SSTR2
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Alteration of somatostatin receptor 2 expression in canine mammary gland tumor." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, (2015) (PubMed).
: "Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall." in: Fitoterapia, Vol. 103, pp. 265-76, (2015) (PubMed).
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: "Alteration of somatostatin receptor 2 expression in canine mammary gland tumor." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, (2015) (PubMed).
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- SSTR2 (Somatostatin Receptor 2 (SSTR2))
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别名
- SSTR2/Somatostatin Receptor 2
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背景
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Synonyms: Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SRIF-1, SSTR2
Background: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
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基因ID
- 6752
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UniProt
- P30874
抗原
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