FLT4 抗体 (AA 920-970) (PE)
Quick Overview for FLT4 抗体 (AA 920-970) (PE) (ABIN737416)
抗原
See all FLT4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 920-970
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from mouse VEGFR3
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亚型
- IgG
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说明
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Exitation/Emission: 480,565nm/578nm
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at 4°C
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有效期
- 12 months
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- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
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别名
- Vegfr3
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背景
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Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
Subcellular location: Cytoplasm
Synonyms: Chy, Flt-4, VEGFR3, VEGFR-3, AI323512, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, Flt4 -
基因ID
- 14257
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UniProt
- P35917
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
抗原
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