APOA1 抗体 (Agarose Beads)
Quick Overview for APOA1 抗体 (Agarose Beads) (ABIN7795843)
抗原
See all APOA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Agarose Beads
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原理
- Goat anti-Human ApoAI Antibody Agarose Immobilized
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纯化方法
- Purified
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免疫原
- Human Apolipoprotein AI
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亚型
- IgG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 5 mg/mL
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缓冲液
- 75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02 % Sodium azide, 0.1 mM PMSF, pH 7.3
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储存液
- Other preservative, PMSF, Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2 - 8 °C
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有效期
- 12 months
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- APOA1 (Apolipoprotein A-I (APOA1))
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别名
- ApoAI
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背景
- Apo AI comprises approximately 70 % of the protein moiety in HDL. It is a single polypeptide chain consisting of 243 amino acid residues without disulfide bound and with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. The molecular weight is reported to be 28 kDa (Brewer et al., 1978). The roles of Apo AI in HDL function include reverse cholesterol transportation, lipid cholesterol binding, lecithin-cholesterol acyl transferase (LCAT) activation, and receptor binding, which is responsible for cholesterol esterification in plasma. Besides participate in cholesterol metabolism, Apo AI and HDL also suppress neutrophil activation, inhibit bacterial endotoxin, induce trypanosomal lysis, and other physiological activities. (Brouillette et al., 2001). Apo AI levels may be inversely related to the risk of coronary disease. In previous research, Apo AI may affect diet-induced inflammation by either directly or indirectly altering lipid rafts. (Cheng et al., 2012)
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基因ID
- 335
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UniProt
- P02647
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途径
- Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism
抗原
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