Recombinant PD-1 抗体
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北京 101111
Quick Overview for Recombinant PD-1 抗体 (ABIN7795529)
抗原
See all PD-1 (PDCD1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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Expression System
- Mammalian cells
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原理
- In Vivo Grade Recombinant Anti-mouse PD-1 / PD-1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 29F.1A12.1 / RMP1-14.1)
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产品特性
- Are you looking for a better anti-mouse PD-1 monoclonal antibody than the clones of RMP1-14 and 29F.1A12. The rat anti-mouse PD-1 monoclonal antibodies (clone No. RMP1-14, rat IgG2a kappa, and clone No. 29F.1A12, rat IgG2a kappa) bind to different epitopes of the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. Both RMP1-14 and 29F.1A12 antibodies block the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein. It is under investigation whether either of the recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (RMP1-14 / 29F.1A12 and 29F.1A12 / RMP1-14) is the best anti-mouse PD1 antibody. Our recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (combination of RMP1-14 and 29F.1A12) have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14 and 29F.1A12).
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纯化方法
- Protein A or G affinity column
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纯度
- >95 % by reducing SDS-PAGE
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method
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亚型
- IgG2c, L234A, L235A, P329G, kappa
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anti-Programmed Cell Death 1 (PDCD1) (AA 201-288) antibody
PDCD1 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 3B3D9 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8G5B12 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 1D6F6 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 3E12A10 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 1-288) antibodyPDCD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) antibodyPDCD1 适用: 人 IHC, ELISA, StM, Coat 宿主: 小鼠 Monoclonal PDCD1-2720 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C3 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- > 3 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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别名
- PD-1 & PD-1
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Sub Type
- Bispecific
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途径
- Cancer Immune Checkpoints
抗原
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