BTLA 抗体 (FineTest®647)
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北京 101111
Quick Overview for BTLA 抗体 (FineTest®647) (ABIN7675483)
抗原
See all BTLA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- FineTest®647 Anti-Mouse CD272 Antibody
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亚型
- IgG1, kappa
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anti-B and T Lymphocyte Associated (BTLA) antibody
BTLA 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 30-183) antibodyBTLA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 179-289) antibodyBTLA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4B12A7 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 31-157) antibodyBTLA 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7B8B4 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 31-157) antibodyBTLA 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 5G1G10 unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 221-289) antibodyBTLA 适用: 人, 小鼠 WB, FACS, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4D6 unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 WB, FACS, IF 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-B and T Lymphocyte Associated (BTLA) antibodyBTLA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-B and T Lymphocyte Associated (BTLA) (AA 30-183) antibodyBTLA 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- 4 °C
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储存方法
- 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- BTLA (B and T Lymphocyte Associated (BTLA))
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别名
- CD272
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背景
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Synonyms: BTLA|B and T lymphocyte attenuator
Background: B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, reduced effectiveness of T regulatory cells. BTLA takes an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4. But further studies are needed to confirm. The existence of three distinct BTLA alleles was reported. The BTLA antibody reacts with mouse BTLA from both BALb/c and C57BL/6 strains.
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分子量
- 0
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基因ID
- 208154
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UniProt
- Q7TSA3
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途径
- Cancer Immune Checkpoints
抗原
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