Haptoglobin 抗体 (AA 180-406)
Quick Overview for Haptoglobin 抗体 (AA 180-406) (ABIN7673380)
抗原
See all Haptoglobin (HP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 180-406
-
原理
- HP antibody
-
纯化方法
- Protein A+G purification
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
-
Immunogen sequence: 180-406aa
Immunogen: haptoglobin
-
亚型
- IgG2a
-
-
-
-
应用备注
- WB: 1:2000 - 1:20000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
有效期
- 12 months
-
-
- Haptoglobin (HP)
-
别名
- HP
-
背景
-
Synonyms: Haptoglobin|Zonulin|Haptoglobin alpha chain|Haptoglobin beta chain|HP
Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
-
分子量
- 42 kDa
-
基因ID
- 3240
-
UniProt
- P00738
-
途径
- Transition Metal Ion Homeostasis
抗原
-