Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
储存条件
4 °C,-20 °C
储存方法
Store at 4°C Valid for 1 month or -20°C Valid for 12 months
有效期
12 months
抗原
ICAM1
(Intercellular Adhesion Molecule 1 (ICAM1))
别名
ICAM-1/CD54
背景
InterceLLuLar adhesion moLecuLe 1,ICAM-1,CD54,Icam1,Icam-1,ICAM-1 (intercellular adhesion molecule-1),also known as CD54,is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated lFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non-integrin ligands including CD43/Sialophorin,Fibrinogen,Hyaluronan,rhinoviruses,and Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 promotes angiogenesis and serves an indicator of vascular endothelial cell activation or damage. Elevated levels of soluble ICAM-1 are associated with cardiovascular disease,type 2 diabetes,organ transplant dysfunction,oxidant stress,increased abdominal fat mass,hypertension,liver disease,certain malignancies,and cerebral malaria.