Optimal working dilution should be determined by the investigator.
限制
仅限研究用
浓度
5 μL/tests
缓冲液
Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.
注意事项
Please protected from prolonged exposure to light and do not freeze.
储存条件
4 °C
储存方法
This product can be stored at 2-8°C for 12 months.
有效期
12 months
抗原
PD-L1
(CD274 (PD-L1))
别名
CD274
背景
B7-H1,PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H,B7H1,PDL1,PDCD1L1,PDCD1LG1,CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.