CD74 抗体
Quick Overview for CD74 抗体 (ABIN7670066)
抗原
See all CD74 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Purified Anti-Human CD74 Antibody[LL1]
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亚型
- IgG1, kappa
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anti-HLA-DR-gamma (CD74) (AA 1-106) antibody
CD74 适用: 人 FACS, WB, ELISA, ICC 宿主: 小鼠 Monoclonal 2D1B3 unconjugated
anti-HLA-DR-gamma (CD74) (AA 78-222) antibodyCD74 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) (AA 64-205) antibodyCD74 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) (AA 1-106) antibodyCD74 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 2D1B11 unconjugated
anti-HLA-DR-gamma (CD74) (AA 73-232) antibodyCD74 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人, 小鼠, Baboon FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal LN-2 unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人 FACS, WB, IF, IHC, IP, ICC 宿主: 小鼠 Monoclonal PIN-1 unconjugated
anti-HLA-DR-gamma (CD74) (N-Term) antibodyCD74 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- ≥ 1 mg/mL
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze / thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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有效期
- 12 months
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- CD74 (HLA-DR-gamma (CD74))
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别名
- CD74
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背景
- HLA class II histocompatibility antigen gamma chain,HLADG,Ia antigen-associated invariant chain,Ia-GAMMA II,Ii,p33,CD74 HLA-DR antigens-associated invariant chain,DHLAG,CD74, invariant chain,CD 74,CD74 antigen,CD74 antigen (invariant polypeptide of major histocompatibility complex,CD74 Molecule,class II antigen-associated),class II invariant chain,CLIP,Gamma chain of class II antigens,HG2A,HLA DR antigens associated invariant chain,HLA DR gamma,HLADR antigens associated invariant chain,HLA-DR antigens-associated invariant chain,HLA-DR-gamma,Ia antigen associated invariant chain,Ia associated invariant chain,Ia gamma,Ia-GAMMA,Invariant polypeptide of major histocompatibility complex class II antigen associated,la-gamma,major histocompatibility complex,Major histocompatibility complex class II invariant chain,MHC HLA DR gamma chain,MHC HLA-DR gamma chain,p35,Protein 41,CD74,DHLAG,HLA class II histocompatibility antigen gamma chain,HLADG,Ia antigen-associated invariant chain,p33,CD 14,CD_antigen=CD14,CD14,CD14 antigen,CD14 Molecule,LPS-R,Mo2,Monocyte differentiation antigen CD14,Monocyte differentiation antigen CD14 urinary form,membrane-bound form,Myeloid cell specific leucine rich glycoprotein,Myeloid cell-specific leucine-rich glycoprotein,Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
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UniProt
- P04233
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途径
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
抗原
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