FLT3 抗体
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北京 101111
Quick Overview for FLT3 抗体 (ABIN7670058)
抗原
See all FLT3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Purified Anti-Human CD135 Antibody[BV10(BV10A4)]
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亚型
- IgG1, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- ≥ 1 mg/mL
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze / thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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有效期
- 12 months
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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别名
- CD135
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背景
- Fetal Liver Kinase,Fms-Like Tyrosine Kinase,Stem Cell Tyrosine Kinase,Receptor-Type Tyrosine-Protein Kinase FLT,FLT,FLK,STK,FLT3,CD135,FLK-2,FLK2,STK1,Fetal Liver Kinase-2,FL Cytokine Receptor,FLT-3,Fms-Like Tyrosine Kinase 3,Receptor-Type Tyrosine-Protein Kinase FLT3,Stem Cell Tyrosine Kinase 1,STK-1,Flt3/Flk2, STK-1,CD 135,CD135 antigen,Fetal liver kinase 2,Flk 2,Flt 3,FMS like tyrosine kinase 3,Fms related tyrosine kinase 3,Fms-Related Tyrosine Kinase 3,Growth factor receptor tyrosine kinase type III,Ly-72,OTTHUMP0000004234,Receptor type tyrosine protein kinase FLT3,Stk 1,Tyrosine protein kinase receptor FLT3,Tyrosine-protein kinase receptor FLT3,This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
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UniProt
- P36888
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途径
- RTK signaling
抗原
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