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Tyrosinase-Related Protein 1 抗体

This anti-Tyrosinase-Related Protein 1 antibody is a 兔 多克隆 antibody detecting Tyrosinase-Related Protein 1 in IHC 和 IHC (fp). Suitable for 人 和 小鼠.
产品编号 ABIN7661551
发货至: 中国
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Quick Overview for Tyrosinase-Related Protein 1 抗体 (ABIN7661551)

抗原

See all Tyrosinase-Related Protein 1 (TYRP1) 抗体
Tyrosinase-Related Protein 1 (TYRP1)

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This Tyrosinase-Related Protein 1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 原理

    Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)

    产品特性

    Reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Recombinant human TYRP1 protein

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Melanoma.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    PBS, 0.05 % BSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    Tyrosinase-Related Protein 1 (TYRP1)

    别名

    Tyrosinase Related Protein-1

    背景

    Synonyms: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP

    Gene Symbol: TYRP1

    Tissue Expression: Melanocytes

    分子量

    75 kDa

    基因ID

    7306

    UniProt

    P17643
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