SREBF1 抗体 (CF®568)
Quick Overview for SREBF1 抗体 (CF®568) (ABIN7660427)
抗原
See all SREBF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SREBP1(SREBP1/1578), CF568 conjugate
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产品特性
- The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human SREBF1 protein
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亚型
- IgG2b, kappa
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anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 38-201) antibody
SREBF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 801-900) antibodySREBF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (pSer439) antibodySREBF1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 1-100) antibodySREBF1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 349-378) antibodySREBF1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21265 unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (Middle Region) antibodySREBF1 适用: 人, 大鼠, 小鼠, Cow, 山羊, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 158-390) antibodySREBF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 461-510) antibodySREBF1 适用: 人, 大鼠, Cow, 山羊, 马, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (Middle Region) antibodySREBF1 适用: 人, 大鼠, 小鼠, Pig, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (AA 250-330) antibodySREBF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: Ubiqutious expression in adult and fetal tissues.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
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别名
- SREBP1
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背景
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Synonyms: ADD 1, bHLHd1, Class D basic helix-loop-helix protein 1, Processed sterol regulatory element-binding protein 1, SREBF1, SREBP1c, SREBP-1, Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1, Sterol regulatory element binding transcription factor 1, Sterol regulatory element-binding transcription factor 1
Gene Symbol: SREBF1
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分子量
- 68/125 kDa mature/precursor
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基因ID
- 6720
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UniProt
- P36956
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途径
- AMPK Signaling, Caspase Cascade in Apoptosis, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
抗原
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