STAT5B 抗体 (CF®640R)
Quick Overview for STAT5B 抗体 (CF®640R) (ABIN7659970)
抗原
See all STAT5B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- STAT5B(STAT5B/2657), CF640R conjugate
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产品特性
- Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human STAT5B protein
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亚型
- IgG
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anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) antibody
STAT5B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C2 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 678-787) antibodySTAT5B 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) antibodySTAT5B 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1A1 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) antibodySTAT5B 适用: 人 WB, IHC (p) 宿主: 兔 Monoclonal 12A1 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 40-280) antibodySTAT5B 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 40-280) antibodySTAT5B 适用: 人 WB, IHC, ELISA, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 180-229) antibodySTAT5B 适用: 人, Cow, 犬, 马, Pig, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (N-Term) antibodySTAT5B 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (pSer731) antibodySTAT5B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) antibodyKO Validated STAT5B 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: Human spleen.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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别名
- STAT5B
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背景
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Synonyms: Signal transducer and activator of transcription 5B, STAT5, Stat5b, Transcription factor STAT5B
Gene Symbol: STAT5B
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分子量
- 94 kDa
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基因ID
- 6777
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UniProt
- P51692
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途径
- JAK/STAT Signaling, RTK signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
抗原
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