Human Papilloma Virus 16 E2 (HPV-16 E2) 抗体 (CF®488A)
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北京 101111
Quick Overview for Human Papilloma Virus 16 E2 (HPV-16 E2) 抗体 (CF®488A) (ABIN7655169)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HPV16 E2 (Human Papilloma Virus 16)(TVG 261), CF488A conjugate
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产品特性
- The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2
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亚型
- IgG1, kappa
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anti-Human Papilloma Virus 16 E2 (HPV-16 E2) antibody
HPV-16 E2 适用: Human Papillomavirus 16 (HPV-16) WB 宿主: 小鼠 Monoclonal TVG 261 unconjugated
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应用备注
- Western blot 1-2 μg/mL, Optimal dilution for a specific application should be determined.
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说明
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Positive Control: HPV-16 infected cells. Cervical tissue.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Human Papilloma Virus 16 E2 (HPV-16 E2)
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别名
- HPV16 E2
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物质类
- Viral Protein
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背景
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Synonyms: HPV16 regulatory protein E2, Human papilloma virus 16 E2, Human papilloma virus 16 regulatory protein E2, Human papillomavirus type 16 E2, Human papillomavirus type 16 regulatory protein E2, Regulatory protein E2
Gene Symbol: Not Applicable
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分子量
- 43 kDa
抗原
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