Human Papilloma Virus 16 E2 (HPV-16 E2) 抗体
The 小鼠 单克隆 anti-Human Papilloma Virus 16 E2 antibody (Clone TVG 261) (ABIN6937435) specifically detects Human Papilloma Virus 16 E2 in WB.
The antibody is reactive with Human Papillomavirus 16 (HPV-16) samples.
产品编号 ABIN6937435
发货至:
中国
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Quick Overview for Human Papilloma Virus 16 E2 (HPV-16 E2) 抗体 (ABIN6937435)
抗原
Human Papilloma Virus 16 E2 (HPV-16 E2)
适用
Human Papillomavirus 16 (HPV-16)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB)
克隆位点
TVG 261
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纯化方法
- Purified by Protein A/G
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免疫原
- Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2
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亚型
- IgG1 kappa
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anti-Human Papilloma Virus 16 E2 (HPV-16 E2) antibody
HPV-16 E2 适用: Human Papillomavirus 16 (HPV-16) WB 宿主: 小鼠 Monoclonal TVG 261 unconjugated
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应用备注
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Positive Control: HPV-16 infected cells. Cervical tissue.
Known Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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缓冲液
- 10 mM PBS without BSA and without Azide.
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储存液
- Azide free
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
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有效期
- 24 months
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- Human Papilloma Virus 16 E2 (HPV-16 E2)
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别名
- HPV16 E2 (Human Papilloma Virus 16)
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物质类
- Viral Protein
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背景
- The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome.
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分子量
- 43kDa
抗原
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