FAT1 抗体 (Cytoplasmic Domain)
Quick Overview for FAT1 抗体 (Cytoplasmic Domain) (ABIN7653925)
抗原
See all FAT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Cytoplasmic Domain
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原理
- FAT1 (FAT atypical cadherin 1)(FAT1-3D7/1)
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产品特性
- The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychiatric disorders, and its action may be of pathophysiological importance. This antibody is available purified, with BSA and azide (0.2 mg/mL) or purified, BSA- and azide-free (1 mg/mL).
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免疫原
- Cytoplasmic domain of Drosophila Fat protein.
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亚型
- IgM, kappa
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anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibody
FAT1 适用: 人 WB 宿主: 小鼠 Monoclonal 4C9 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (AA 4203-4539) antibodyFAT1 适用: 人 WB 宿主: 小鼠 Monoclonal 1634CT464-1-9 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (Cytoplasmic Domain) antibodyFAT1 适用: Drosophila melanogaster ELISA, WB, Coat, IF 宿主: 小鼠 Monoclonal FAT1-3D7-1 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: Wild type imaginal discs from third instar Drosophila larvae.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- PBS, 0.05 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
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别名
- FAT1
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背景
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Synonyms: Cadherin family member 7 precursor (CDHF7), Cadherin ME5, Cadherin related tumor suppressor homolog precursor (FAT protein homolog), FAT tumor suppressor homolog 1, hFat 1, Homolog of Drosophila tumor suppressor FAT precursor, nuclear form, Protein fat homolog, Protocadherin Fat 1
Gene Symbol: FAT1
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分子量
- 500 kDa
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基因ID
- 2195
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UniProt
- Q14517
抗原
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