DMC1 抗体 (CF®405S)
Quick Overview for DMC1 抗体 (CF®405S) (ABIN7653208)
抗原
See all DMC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- DMC1(2H12/4), CF405S conjugate
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产品特性
- DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human DMC1 protein.
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亚型
- IgG2a, kappa
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anti-DNA Meiotic Recombinase 1 (DMC1) (AA 237-339) antibody
DMC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A10 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 5-153) antibodyDMC1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) antibodyDMC1 适用: 人, 小鼠, 大鼠, Cow WB, IHC, IF, StM 宿主: 小鼠 Monoclonal 2H12-4 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (Center) antibodyDMC1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) antibodyDMC1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 237-339) antibodyDMC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (Internal Region) antibodyDMC1 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-260) antibodyDMC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-30), (N-Term) antibodyDMC1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23872 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-30), (N-Term) antibodyDMC1 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: HeLa cells. Cervix or prostate.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- DMC1 (DNA Meiotic Recombinase 1 (DMC1))
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别名
- DMC1
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背景
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Synonyms: Disrupted meiotic cDNA 1 homolog, dJ199H16.1, DMC1 dosage suppressor of mck1 homolog, DMC1H, DNA meiotic recombinase 1, HsLim15, LIM15, Meiotic recombination protein DMC1/LIM15 homolog, MGC150472, MGC150473
Gene Symbol: DMC1
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分子量
- 37 kDa
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基因ID
- 11144
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UniProt
- Q14565
抗原
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