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N-Cadherin 抗体 (Extracellular Domain) (CF®740)

Name: N-Cadherin 抗体 (Extracellular Domain) (CF®740)
SKU: ABIN7650242
Availability: OutOfStock

This anti-N-Cadherin antibody is a 小鼠单克隆 antibody detecting N-Cadherin in IHC 和 IHC (fp). Suitable for 人和小鼠.

产品编号 ABIN7650242

发货至: 中国

Quick Overview for N-Cadherin 抗体 (Extracellular Domain) (CF®740) (ABIN7650242)

抗原

See all N-Cadherin (CDH2) 抗体

N-Cadherin (CDH2) (Cadherin 2 (CDH2))

适用

人, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This N-Cadherin antibody is conjugated to CF®740

应用范围

Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

克隆位点

8C11

Discover our top product CDH2 Primary Antibody

抗原表位
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1
Extracellular Domain

原理

N-Cadherin / Cadherin-2 / CD325 (NCAD) (8C11), CF740 conjugate

产品特性

This antibody recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

免疫原

Recombinant human N-cadherin extracellular domain

亚型

IgG1, kappa
anti-Cadherin 2 (CDH2) (AA 701-800) antibody
CDH2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) antibody
CDH2 适用: 人, 小鼠, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2G7 unconjugated

anti-Cadherin 2 (CDH2) (AA 750-850) antibody
CDH2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) antibody
CDH2 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 5D5 unconjugated

anti-Cadherin 2 (CDH2) (AA 45-238) antibody
CDH2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (AA 685-784) antibody
CDH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (AA 295-414) antibody
CDH2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cadherin 2 (CDH2) (Extracellular Domain) antibody
CDH2 适用: 人 WB, IHC, IF, FACS, IHC (f) 宿主: 小鼠 Monoclonal 8C11 unconjugated

anti-Cadherin 2 (CDH2) antibody
CDH2 适用: 人 WB, IHC, IHC (f) 宿主: 兔 Monoclonal unconjugated Recombinant Antibody

anti-Cadherin 2 (CDH2) (AA 701-714), (Middle Region) antibody
CDH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunofluorescence: 1-2 μg/mL. Immunohistology (formalin): 0.5-1 μg/mL. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris, 1 mM EDTA pH 9.0 for 10-20 min followed by cooling at RT for 20 min. Flow Cytometry 0.5-1 μg/million cells/0.1 mL. Western blotting 0.5-1 μg/mL. Optimal dilution for a specific application should be determined by user

说明

Positive Control: HeLa or HUVEC cells. Heart, Pancreas or Cerebral Cortex

限制

仅限研究用
状态

Liquid

浓度

0.1 mg/mL

缓冲液

PBS, 0.1 % rBSA, 0.05 % azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Protect from light

储存条件

4 °C

储存方法

Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light

有效期

24 months
抗原

N-Cadherin (CDH2) (Cadherin 2 (CDH2))

别名

Cadherin-2

背景

Synonyms: Cadherin-2 N cadherin neuronal, Cadherin-2 type 1, Cadherin-2, Calcium dependent adhesion protein neuronal, CD325, CDH2, CDHN, CDw325, N-Cadherin, NCAD
Gene Symbol: CDH2

分子量

130-140 kDa

基因ID

1000

UniProt

P19022

途径

Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane