OGG1 抗体 (CF®647)
Quick Overview for OGG1 抗体 (CF®647) (ABIN7649055)
抗原
See all OGG1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- 8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF647 conjugate
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产品特性
- 8-Oxoguanine DNA Glycosylase (OGG1), otherwise known as N-Glycosylase/DNA lyase, is the enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base by-product which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Defects in OGG1 may be a cause of renal cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human OGG1 protein
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亚型
- IgG2c, kappa
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anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-100), (N-Term) antibody
OGG1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IP, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 31-345) antibodyOGG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 151-250) antibodyOGG1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-345) antibodyOGG1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-324) antibodyOGG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-324) antibodyOGG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibodyVerified OGG1 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) antibodyOGG1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CPTC-OGG1-1 unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 31-345) antibodyOGG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: HeLa or Jurkat cells. Kidney, skin or lymph node.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
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别名
- N-Glycosylase/DNA lyase
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背景
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Synonyms: 8-oxoguanine DNA glycosylase, HMMH, HOGG1, MUTM, OGH1
Gene Symbol: OGG1
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分子量
- 39 kDa
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基因ID
- 4968
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UniProt
- O15527
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途径
- DNA Damage Repair
抗原
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