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KLRK1 抗体 (AA 121-219)

Name: KLRK1 抗体 (AA 121-219)
SKU: ABIN730078
Availability: OutOfStock

This 兔多克隆 antibody specifically detects KLRK1 in WB, FACS, ELISA, IHC (fro), IF (cc), IF (p) 和 IHC (p). It exhibits reactivity toward 小鼠. It has been mentioned in 3+ publications

Formalin-fixed and paraffin embedded human nasopharyngeal carcinoma labeled with Anti-NKG2D/CD314/KLRK1 Polyclonal Antibody, Unconjugated (ABIN730078) at 1:200, followed by conjugation to the secondary antibody and DAB staining (KLRK1 抗体 (AA 121-219))

IHC

Thymus cells probed with NKG2D Polyclonal Antibody, unconjugated at 1:100 dilution for 30 minutes compared to control cells (blue) and isotype control (orange) (KLRK1 抗体 (AA 121-219))

IHC (p)

Paraformaldehyde-fixed, paraffin embedded mouse lymph node tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-NKG2D Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining (KLRK1 抗体 (AA 121-219))

IHC (p)

4 images

(3 references)

产品编号 ABIN730078

发货至: 中国

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中国
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Quick Overview for KLRK1 抗体 (AA 121-219) (ABIN730078)

抗原

See all KLRK1 抗体

KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This KLRK1 antibody is un-conjugated

应用范围

Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product KLRK1 Primary Antibody

抗原表位
15

6

2

2

2

2

2

2

2

1

1

1

1

1

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1

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1
AA 121-219

交叉反应

小鼠

预测反应

Human,Rat

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from rat KLRK1

亚型

IgG
anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (AA 73-216) antibody
KLRK1 适用: 人, 大鼠 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 5C9B4 unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) antibody (FITC)
KLRK1 适用: 人 FACS 宿主: 小鼠 Monoclonal 1D11 FITC

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) antibody
KLRK1 适用: 人 FACS, IP, IHC (fro), Func 宿主: 小鼠 Monoclonal 1D11 unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) antibody
KLRK1 适用: 人 FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal 1D11 unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) antibody
KLRK1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (AA 73-216) antibody
KLRK1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (AA 92-216) antibody
KLRK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (AA 90-232) antibody
KLRK1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (AA 75-215) antibody
KLRK1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (Internal Region) antibody
Verified KLRK1 适用: 人 WB, FACS, ELISA 宿主: 山羊 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Mozer-Lisewska, Mania, Kowala-Piaskowska, Kluk, Samara, Pauli, ?eromski: "Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers." in: Archivum immunologiae et therapiae experimentalis, Vol. 62, Issue 2, pp. 153-60, (2014) (PubMed).

Onishi, Kiyota, Koya, Tanaka, Umebayashi, Katano, Morisaki: "Random migration contributes to cytotoxicity of activated CD8+ T-lymphocytes but not NK cells." in: Anticancer research, Vol. 34, Issue 8, pp. 3947-56, (2014) (PubMed).

Ruck, Bittner, Gross, Breuer, Albrecht, Korr, Göbel, Pankratz, Henschel, Schwab, Staszewski, Prinz, Kuhlmann, Meuth, Wiendl: "CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation." in: PLoS ONE, Vol. 8, Issue 11, pp. e81455, (2013) (PubMed).
抗原

KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

别名

NKG2D

背景

Synonyms: NKG2D, Nkrp2, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NK lectin-like receptor, NKLLR, NKG2-D-activating NK receptor, NKR-P2, CD314, Klrk1
Background: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.

基因ID

24934

UniProt

O70215

途径

Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process