KLRK1 抗体 (AA 73-216)
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- 抗原 See all KLRK1 抗体
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
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抗原表位
- AA 73-216
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KLRK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human NKG2-D type II integral membrane protein (73-216AA)
- 亚型
- IgG
- Top Product
- Discover our top product KLRK1 Primary Antibody
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- 别名
- KLRK1 (KLRK1 产品)
- 别名
- KLRK1 antibody, NKG2D antibody, CD314 antibody, D12S2489E antibody, KLR antibody, NKG2-D antibody, D6H12S2489E antibody, Nkg2d antibody, Nkrp2 antibody, killer cell lectin like receptor K1 antibody, killer cell lectin-like receptor subfamily K, member 1 antibody, NKG2D protein antibody, KLRK1 antibody, Klrk1 antibody, NKG2D antibody
- 背景
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Background: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Aliases: CD314 antibody, CD314 antigen antibody, D12S2489E antibody, Killer cell lectin like receptor subfamily K member 1 antibody, Killer cell lectin-like receptor subfamily K member 1 antibody, KLR antibody, KLRC4 KLRK1 readthrough antibody, KLRK1 antibody, NK cell receptor D antibody, NK lectin-like receptor antibody, NKG2 D activating NK receptor antibody, NKG2 D type II integral membrane protein antibody, NKG2-D antibody, NKG2-D type II integral membrane protein antibody, NKG2-D-activating NK receptor antibody, Nkg2d antibody, NKG2D_HUMAN antibody, NKLLR antibody, NKR P2 antibody, Nkrp2 antibody
- UniProt
- P26718
- 途径
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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