PD-L1 抗体 (Biotin)
Quick Overview for PD-L1 抗体 (Biotin) (ABIN7608339)
抗原
See all PD-L1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
 - Biotinylated Anti-PD-L1 antibody(DM123), Rabbit mAb
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纯化方法
 - Purified from cell culture supernatant by affinity chromatography
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亚型
 - IgG
 
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应用备注
 - ELISA 1:5000-10000, Flow Cyt 1:100
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限制
 - 仅限研究用
 
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状态
 - Lyophilized
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缓冲液
 - Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
 - -20 °C,-80 °C
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储存方法
 - Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
 - 12 months
 
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- PD-L1 (CD274 (PD-L1))
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别名
 - PDL1
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背景
 - This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
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UniProt
 - Q9NZQ7
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途径
 - Cancer Immune Checkpoints
 
抗原
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