SPOP-B 抗体 (N-Term)
Quick Overview for SPOP-B 抗体 (N-Term) (ABIN7603237)
抗原
See all SPOP-B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-SPOP Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SPOP Antibody Picoband® (ABIN7603237). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human SPOP, identical to the related mouse sequences.
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亚型
- IgG
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anti-Speckle-Type POZ Protein (SPOP-B) (Internal Region) antibody
SPOP-B 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (AA 301-374) antibodySPOP-B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (AA 1-374) antibodySPOP-B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (Center) antibodySPOP-B 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (C-Term) antibodySPOP-B 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (AA 48-374) antibodySPOP-B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (AA 74-107), (N-Term) antibodySPOP-B 适用: 小鼠, 斑马鱼 WB 宿主: 兔 Polyclonal RB49885 unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (AA 1-374) antibodySPOP-B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (C-Term) antibodySPOP-B 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 豚鼠, 马, 兔, 小鸡, 非洲爪蟾, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Speckle-Type POZ Protein (SPOP-B) (AA 1-193) antibodySPOP-B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
1. Barbieri, C. E., Baca, S. C., Lawrence, M. S., Demichelis, F., Blattner, M., Theurillat, J.-P., White, T. A., Stojanov, P., Van Allen, E., Stransky, N., Nickerson, E., Chae, S.-S., and 34 others. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nature Genet. 44: 685-689, 2012. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/10/2019. 3. Le Gallo, M., O'Hara, A. J., Rudd, M. L., Urick, M. E., Hansen, N. F., O'Neil, N. J., Price, J. C., Zhang, S., England, B. M., Godwin, A. K., Sgroi, D. C., NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Hieter, P., Mullikan, J. C., Merino, M. J., Bell, D. W. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nature Genet. 44: 1310-1315, 2012. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
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别名
- SPOP
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背景
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Synonyms: Tripartite motif-containing protein 6, RING finger protein 89, RING-type E3 ubiquitin transferase TRIM6, TRIM6, RNF89
Tissue Specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. .
Background: Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
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分子量
- 50 kDa
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基因ID
- 8405
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UniProt
- O43791
抗原
-
