GRID2 抗体 (N-Term)
Quick Overview for GRID2 抗体 (N-Term) (ABIN7603172)
抗原
See all GRID2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-GRID2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GRID2 Antibody Picoband® (ABIN7603172). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human GRID2, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (C-Term) antibody
GRID2 适用: 人, 大鼠, 小鼠 WB, IF, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 908-1007) antibodyGRID2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A1 unconjugated
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (C-Term) antibodyGRID2 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 908-1007) antibodyGRID2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 831-880) antibodyGRID2 适用: 人, 大鼠, 小鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 206-218), (Extracellular) antibodyGRID2 适用: 大鼠 WB, IF, IC, IHC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (C-Term) antibodyGRID2 适用: 人, 大鼠, 小鼠, 斑马鱼 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human, Rat
1. Araki, K., Meguro, H., Kushiya, E., Takayama, C., Inoue, Y., Mishina, M. Selective expression of the glutamate receptor channel delta-2 subunit in cerebellar Purkinje cells. Biochem. Biophys. Res. Commun. 197: 1267-1276, 1993. 2. Hills, L. B., Masri, A., Konno, K., Kakegawa, W., Lam, A.-T. N., Lim-Melia, E., Chandy, N., Hill, R. S., Partlow, J. N., Al-Saffar, M., Nasir, R., Stoler, J. M., Barkovich, A. J., Watanabe, M., Yuzaki, M., Mochida, G. H. Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans. Neurology 81: 1378-1386, 2013. 3. Hirai, H., Launey, T., Mikawa, S., Torashima, T., Yanagihara, D., Kasaura, T., Miyamoto, A., Yuzaki, M. New role of delta-2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neurosci. 6: 869-876, 2003. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))
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别名
- GRID2
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背景
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Synonyms: Loricrin, LOR, LRN
Tissue Specificity: Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
Background: Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ2, is a protein that in humans is encoded by the GRID2 gene. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
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分子量
- 113 kDa
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基因ID
- 2895
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UniProt
- O43424
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途径
- Synaptic Membrane
抗原
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