PITX2 抗体 (N-Term)
Quick Overview for PITX2 抗体 (N-Term) (ABIN7603131)
抗原
See all PITX2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-PITX2/RGS Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PITX2/RGS Antibody Picoband® (ABIN7603131). Tested in Flow Cytometry, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human PITX2/RGS, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Paired-Like Homeodomain 2 (PITX2) (AA 40-154) antibody
PITX2 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (N-Term) antibodyPITX2 适用: 人, 大鼠, 小鼠, Pig, 兔, Cow, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-271) antibodyPITX2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 20-69) antibodyPITX2 适用: 人, 小鼠, Pig, Cow, 猴, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 122-151) antibodyPITX2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) antibodyPITX2 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 1-324) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Paired-Like Homeodomain 2 (PITX2) (AA 189-270) antibodyPITX2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Arakawa H, Nakamura T, Zhadanov AB, Fidanza V, Yano T, Bullrich F, Shimizu M, Blechman J, Mazo A, Canaani E, Croce CM (Apr 1998). "Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene". Proceedings of the National Academy of Sciences of the United States of America. 95 (8): 4573-8. 2. L'honoré A, Ouimette JF, Lavertu-Jolin M, Drouin J (Nov 2010). "Pitx2 defines alternate pathways acting through MyoD during limb and somitic myogenesis". Development. 137 (22): 3847-56. 3. Héon E, Sheth BP, Kalenak JW, Sunden SL, Streb LM, Taylor CM, Alward WL, Sheffield VC, Stone EM (Aug 1995). "Linkage of autosomal dominant iris hypoplasia to the region of the Rieger syndrome locus (4q25)". Human Molecular Genetics. 4 (8): 1435-9. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PITX2 (Paired-Like Homeodomain 2 (PITX2))
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别名
- PITX2
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背景
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Synonyms: Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1
Tissue Specificity: Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.
Background: Paired-like homeodomain transcription factor 2?also known as?pituitary homeobox 2?is a?protein?that in humans is encoded by the?PITX2?gene. It is mapped to 4q25. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
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分子量
- 35 kDa
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基因ID
- 5308
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UniProt
- Q99697
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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