CCR6 抗体 (N-Term)
Quick Overview for CCR6 抗体 (N-Term) (ABIN7603110)
抗原
See all CCR6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-CCR6 Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CCR6 Picoband® Antibody (ABIN7603110). Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human CCR6, which shares 70.6% and 76.5% amino acid (aa) sequence identity with mouse and rat CCR6, respectively.
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亚型
- IgG
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anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibody
CCR6 适用: 人 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 7C6D9 unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 201-300) antibodyCCR6 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (C-Term) antibodyCCR6 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 322-374) antibodyCCR6 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibodyCCR6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (N-Term) antibodyCCR6 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibodyCCR6 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (C-Term) antibodyCCR6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (C-Term) antibodyCCR6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (N-Term) antibodyCCR6 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
1. Bracke, K. R., D'hulst, A. I., Maes, T., Moerloose, K. B., Demedts, I. K., Lebecque, S., Joos, G. F., Brusselle, G. G. Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J. Immun. 177: 4350-4359, 2006. 2. Homey, B., Dieu-Nosjean, M.-C., Wiesenborn, A., Massacrier, C., Pin, J.-J., Oldham, E., Catron, D., Buchanan, M. E., Muller, A., de Waal Malefyt, R., Deng, G., Orozco, R., Ruzicka, T., Lehmann, P., Lebecque, S., Caux, C., Zlotnik, A. Up-regulation of macrophage inflammatory protein-3-alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immun. 164: 6621-6632, 2000. 3. Klose, C. S. N., Kiss, E. A., Schwierzeck, V., Ebert, K., Hoyler, T., d'Hargues, Y., Goppert, N., Croxford, A. L., Waisman, A., Tanriver, Y., Diefenbach, A. A T-bet gradient controls the fate and function of CCR6(-)ROR-gamma-t(+) innate lymphoid cells. Nature 494: 261-265, 2013. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))
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别名
- CCR6
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背景
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Synonyms: C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, Chemokine receptor-like 3, CKR-L3, DRY6, G-protein coupled receptor 29, GPR-CY4, GPRCY4, LARC receptor, CD196, CCR6, CKRL3, CMKBR6, GPR29, STRL22
Tissue Specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Background: Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. It is mapped to 6q27. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
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分子量
- 78 kDa
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基因ID
- 1235
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UniProt
- P51684
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途径
- cAMP Metabolic Process
抗原
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