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- 抗原 See all CCR6 抗体
- CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CCR6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- CCR6 Antibody detects endogenous levels of total CCR6.
- 预测反应
- Horse,Sheep
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CCR6, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CCR6 Primary Antibody
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anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibody
CCR6 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7C6D9 unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 201-300) antibodyCCR6 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (N-Term) antibodyCCR6 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibodyCCR6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 322-374) antibodyCCR6 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 18-46) antibodyCCR6 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 18-46) antibodyCCR6 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (C-Term) antibodyCCR6 适用: 人, 猴, Gorilla IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))
- 别名
- CCR6 (CCR6 产品)
- 别名
- BN-1 antibody, C-C CKR-6 antibody, CC-CKR-6 antibody, CCR-6 antibody, CD196 antibody, CKR-L3 antibody, CKRL3 antibody, CMKBR6 antibody, DCR2 antibody, DRY6 antibody, GPR29 antibody, GPRCY4 antibody, STRL22 antibody, Cmkbr6 antibody, KY411 antibody, C-C motif chemokine receptor 6 antibody, chemokine (C-C motif) receptor 6 antibody, CCR6 antibody, Ccr6 antibody
- 背景
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Description: Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
Gene: CCR6
- 分子量
- 42 kDa
- 基因ID
- 1235
- UniProt
- P51684
- 途径
- cAMP Metabolic Process
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