Interleukin 17a 抗体 (Middle Region)
Quick Overview for Interleukin 17a 抗体 (Middle Region) (ABIN7603062)
抗原
See all Interleukin 17a (IL17A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- Anti-IL17A Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-IL17A Antibody Picoband® (ABIN7603062). Tested in IHC applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human IL17A, which shares 88.2% amino acid (aa) sequence identity with mouse and rat IL17A.
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亚型
- IgG
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anti-Interleukin 17A (IL17A) (AA 1-75) antibody
IL17A 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4K5F6 unconjugated
anti-Interleukin 17A (IL17A) (Internal Region) antibodyIL17A 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 17A (IL17A) antibodyIL17A 适用: 人 ELISA, WB, Neut 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin 17A (IL17A) antibodyIL17A 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 17A (IL17A) (AA 24-133) antibodyIL17A 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3G5 unconjugated
anti-Interleukin 17A (IL17A) antibodyIL17A 适用: 人 ELISA, FACS, ICC, IP 宿主: 小鼠 Monoclonal 9F9 unconjugated
anti-Interleukin 17A (IL17A) antibody (FITC)IL17A 适用: 人 ICFC 宿主: 小鼠 Monoclonal 9F9 FITC
anti-Interleukin 17A (IL17A) antibody (APC)IL17A 适用: 人 ICFC 宿主: 小鼠 Monoclonal 9F9 APC
anti-Interleukin 17A (IL17A) antibody (PE)IL17A 适用: 人 FACS 宿主: 小鼠 Monoclonal 9F9 PE
anti-Interleukin 17A (IL17A) (AA 24-155) antibodyIL17A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL/mL, Human
1. Allen, C. E., McClain, K. L. Interleukin-17A is not expressed by CD207+ cells in Langerhans cell histiocytosis lesions. (Letter) Nature Med. 15: 483-484, 2009. 2. Amadi-Obi, A., Yu, C.-R., Liu, X., Mahdi, R. M., Clarke, G. L., Nussenblatt, R. B., Gery, I., Lee, Y. S., Egwuagu, C. E. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nature Med. 13: 711-718, 2007. 3. Arico, M., Henter, J.-I., Egeler, R. M., Delprat, C. Reply to Allen and McClain. (Letter) Nature Med. 15: 484-485, 2009. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
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别名
- IL17A
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背景
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Synonyms: Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, Il17a, Ctla8, Il17
Tissue Specificity: Restricted to a subset of activated T-cells.
Background: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A
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分子量
- 27 kDa
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基因ID
- 3605
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UniProt
- Q16552
抗原
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