JAK2 抗体 (Cytoplasmic Domain, Cytosolic)
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Quick Overview for JAK2 抗体 (Cytoplasmic Domain, Cytosolic) (ABIN7602956)
抗原
See all JAK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Cytoplasmic Domain, Cytosolic
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原理
- Anti-JAK2 Monoclonal Antibody
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产品特性
- Anti-JAK2 Monoclonal Antibody (ABIN7602956). Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human JAK2 Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
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亚型
- IgG
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anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人, 大鼠, 小鼠, 兔, 斑马鱼 WB, ELISA, ICC, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 508-800) antibodyJAK2 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 916-1103) antibodyJAK2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 745-955) antibodyJAK2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5C12C9 unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr221) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr931) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibodyJAK2 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 1A4 unconjugated Recombinant Antibody
anti-Janus Kinase 2 (JAK2) (C-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 1101-1132) antibodyJAK2 适用: 人, 小鼠 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (N-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:500-2000
IHC 1:50-200
ICC/IF 1:50-200
IP 1:50-100
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
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浓度
- 0.5 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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- JAK2 (Janus Kinase 2 (JAK2))
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别名
- JAK2
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背景
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Synonyms: Signal transducer and activator of transcription 3,Acute-phase response factor,STAT3,APRF,
Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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分子量
- 131 kDa
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UniProt
- O60674
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途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
抗原
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