FKBP4 抗体 (C-Term)
Quick Overview for FKBP4 抗体 (C-Term) (ABIN7602883)
抗原
See all FKBP4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-FKBP52/FKBP4 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-FKBP52/FKBP4 Antibody Picoband® (ABIN7602883). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human FKBP52/FKBP4, which shares 94.7% amino acid (aa) sequence identity with mouse and rat FKBP4.
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亚型
- IgG
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anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 301-410) antibody
FKBP4 适用: 人 WB, IP, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5C11 unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 2-459) antibodyFKBP4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) antibodyFKBP4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) antibodyFKBP4 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) (AA 220-459) antibodyFKBP4 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibodyFKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibodyFKBP4 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibody (HRP)FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C HRP
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibody (FITC)FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C FITC
anti-FK506 Binding Protein 4, 59kDa (FKBP4) antibody (Biotin)FKBP4 适用: 人 WB, IHC, IP, IF, ICC 宿主: 小鼠 Monoclonal Hi52C Biotin
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
1. Chambraud, B., Radanyi, C., Camonis, J. H., Rajkowski, K., Schumacher, M., Baulieu, E.-E. Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-CoA alpha-hydroxylase is a new FKBP-associated protein. Proc. Nat. Acad. Sci. 96: 2104-2109, 1999. 2. Chen, H., Yong, W., Hinds, T. D., Jr., Yang, Z., Zhou, Y., Sanchez, E. R., Shou, W. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J. Biol. Chem. 285: 27776-27784, 2010. 3. Cheung-Flynn, J., Prapapanich, V., Cox, M. B., Riggs, D. L., Suarez-Quian, C., Smith, D. F. Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Molec. Endocr. 19: 1654-1666, 2005. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
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别名
- FKBP4
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背景
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Synonyms: Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, Group-VIIA phospholipase A2, gVIIA-PLA2, LDL-associated phospholipase A2, LDL-PLA (2), PAF 2-acylhydrolase, PLA2G7, PAFAH
Tissue Specificity: Plasma.
Background: FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
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分子量
- 56-59 kDa
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基因ID
- 2288
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UniProt
- Q02790
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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