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DDC 抗体 (C-Term)

This anti-DDC antibody is a 兔 多克隆 antibody detecting DDC in WB 和 FACS. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7602877
发货至: 中国

Quick Overview for DDC 抗体 (C-Term) (ABIN7602877)

抗原

See all DDC 抗体
DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

适用

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人, 小鼠, 大鼠

宿主

  • 67
  • 10
  • 2
  • 2

克隆类型

  • 65
  • 16
多克隆

标记

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  • 2
  • 1
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This DDC antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS)
  • 抗原表位

    • 15
    • 12
    • 11
    • 8
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    C-Term

    原理

    Anti-DOPA decarboxylase/DDC Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-DOPA decarboxylase/DDC Antibody Picoband® (ABIN7602877). Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human DOPA decarboxylase/DDC, which shares 76% amino acid (aa) sequence identity with both mouse and rat DOPA decarboxylase/DDC.

    亚型

    IgG
  • 应用备注

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., Levitt, P. A transient placental source of serotonin for the fetal forebrain. Nature 472: 347-350, 2011. 2. Brun, L., Ngu, L. H., Keng, W. T., Ch'ng, G. S., Choy, Y. S., Hwu, W. L., Lee, W. T., Willemsen, M. A. A. P., Verbeek, M. M., Wassenberg, T., Regal, L., Orcesi, S., and 13 others. Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Neurology 75: 64-71, 2010. Note: Erratum: Neurology 75: 576 only, 2010. 3. Bruneau, G., Gross, M.-S., Krieger, M., Bernheim, A., Thibault, J., Nguyen, V. C. Preparation of a human DOPA decarboxylase cDNA probe by PCR and its assignment to chromosome 7. Ann. Genet. 33: 208-213, 1990.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    储存条件

    4 °C,-20 °C

    储存方法

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原

    DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

    别名

    DDC

    背景

    Synonyms: DDC, AADC, Aromatic-L-amino-acid decarboxylase, AADC, EC 4.1.1.28, DOPA decarboxylase, DDC

    Background: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

    分子量

    50 kDa

    基因ID

    1644

    UniProt

    P20711

    途径

    Dopaminergic Neurogenesis
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