BIM 抗体 (C-Term)
Quick Overview for BIM 抗体 (C-Term) (ABIN7602855)
抗原
See all BIM (BCL2L11) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-Bim/BCL2L11 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Bim/BCL2L11 Antibody Picoband® (ABIN7602855). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Bim/BCL2L11, which shares 80% amino acid (aa) sequence identity with mouse and rat BCL2L11.
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亚型
- IgG
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anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 2-120) antibody
BCL2L11 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer87) antibodyBCL2L11 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-198) antibodyBCL2L11 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 134-160) antibodyBCL2L11 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22105 unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Middle Region) antibodyBCL2L11 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 51-150) antibodyBCL2L11 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibodyBCL2L11 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 130-165) antibodyBCL2L11 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00963 unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibodyBCL2L11 适用: 人, 小鼠, 大鼠, Cow, 绵羊 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 130-165) antibodyBCL2L11 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Kontgen, F., Adams, J. M., Strasser, A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738, 1999. 2. Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M., Strasser, A. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415: 922-926, 2002. Note: Erratum: Nature 618: 108 only, 2002. 3. Bouillet, P., Zhang, L. C., Huang, D. C. S., Webb, G. C., Bottema, C. D. K., Shore, P., Eyre, H. J., Sutherland, G. R., Adams, J. M. Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mammalian Genome 12: 163-168, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
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别名
- BCL2L11
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背景
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Synonyms: Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB
Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Background: Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
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分子量
- 28 kDa
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基因ID
- 10018
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UniProt
- O43521
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途径
- PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
抗原
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