APH1A 抗体 (C-Term)
Quick Overview for APH1A 抗体 (C-Term) (ABIN7602846)
抗原
See all APH1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-APH1A Antibody Picoband®
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产品特性
- Anti-APH1A Antibody Picoband® (ABIN7602846). Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human APH1A, identical to the related mouse sequences.
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anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 71-170) antibody
APH1A 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (Internal Region) antibodyVerified APH1A 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (C-Term) antibodyAPH1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 90-118) antibodyAPH1A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 80-130) antibodyAPH1A 适用: 人, Cow, 犬, 马, 猴, Opossum WB 宿主: 兔 Polyclonal unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (AA 77-109), (N-Term) antibodyAPH1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4994 unconjugated
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) (Middle Region) antibodyAPH1A 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg /1x106 cells, Human
1. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himes, C. S., Hiebsch, R., Ruble, C., Nye, J. S., Curtis, D. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of beta-APP, and presenilin protein accumulation. Dev. Cell 3: 85-97, 2002. 2. Goutte, C., Tsunozaki, M., Hale, V. A., Priess, J. R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Nat. Acad. Sci. 99: 775-779, 2002. 3. Goutte, C. Genetics leads the way to the accomplices of presenilins. (Commentary) Dev. Cell 3: 6-7, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
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别名
- APH1A
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背景
- This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
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分子量
- 29 kDa
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基因ID
- 51107
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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