Renin 抗体 (C-Term)
Quick Overview for Renin 抗体 (C-Term) (ABIN7602836)
抗原
See all Renin (REN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-REN/Renin Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-REN/Renin Antibody Picoband® (ABIN7602836). Tested in IHC applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human REN/Renin, which shares 95% and 95% amino acid (aa) sequence identity with mouse and rat REN/Renin, respectively.
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亚型
- IgG
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anti-Renin (REN) (AA 67-153) antibody
REN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Renin (REN) (AA 24-406) antibodyREN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H2 unconjugated
anti-Renin (REN) (Internal Region) antibodyREN 适用: 人, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Renin (REN) (AA 331-406) antibodyREN 适用: 大鼠, 小鼠, 犬 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Renin (REN) (AA 67-153) antibodyREN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D2 unconjugated
anti-Renin (REN) (AA 275-389) antibodyREN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 3# unconjugated
anti-Renin (REN) (AA 65-264) antibodyREN 适用: 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Renin (REN) (AA 229-398) antibodyREN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Renin (REN) antibodyREN 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Renin (REN) (AA 24-406) antibodyREN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B5 unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. Abel, K. J., Gross, K. W. Close physical linkage of the murine Ren-1 and Ren-2 loci. Nucleic Acids Res. 16: 2111-2126, 1988. 2. Caron, K. M. I., James, L. R., Kim, H.-S., Knowles, J., Uhlir, R., Mao, L., Hagaman, J. R., Cascio, W., Rockman, H., Smithies, O. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc. Nat. Acad. Sci. 101: 3106-3111, 2004. 3. Chirgwin, J. M., Schaefer, I. M., Diaz, J. A., Lalley, P. A. Mouse kidney renin gene is on chromosome one. Somat. Cell Molec. Genet. 10: 633-637, 1984. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Renin (REN)
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别名
- REN
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背景
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Synonyms: p-selectin glycoprotein ligand, Selplg, Psgl1
Tissue Specificity: Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.
Background: This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.
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分子量
- 53-60 kDa
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基因ID
- 5972
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UniProt
- P00797
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途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
抗原
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