SOD2 抗体 (C-Term)
Quick Overview for SOD2 抗体 (C-Term) (ABIN7602799)
抗原
See all SOD2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- Anti-SOD2 Antibody Picoband® (monoclonal, 2B12B1)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SOD2 Antibody Picoband® (monoclonal, 2B12B1) (ABIN7602799). Tested in IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human SOD2, different from the related mouse sequence by one amino acid, and from the related rat sequence by four amino acids.
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亚型
- IgG2b
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anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 25-222) antibody
SOD2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 25-222) antibodySOD2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 1-222) antibodySOD2 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 8H3D2 unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 1-222) antibodySOD2 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 8H3F9 unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) antibodySOD2 适用: 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 41-78) antibodySOD2 适用: 人, 小鼠, Pig, 绵羊 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 25-222) antibodySOD2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 64-175) antibodySOD2 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 119-130) antibodyVerified SOD2 适用: 人, 大鼠, 小鼠, Pig WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) antibodySOD2 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. Bastaki, M., Huen, K., Manzanillo, P., Chande, N., Chen, C., Balmes, J. R., Tager, I. B., Holland, N. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. Pharmacogenet. Genomics 16: 279-286, 2006. 2. Creagan, R., Tischfield, J., Ricciuti, F., Ruddle, F. H. Chromosome assignments of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase-B, tetrameric) to chromosome 6. Humangenetik 20: 203-209, 1973. 3. Hiroi, S., Harada, H., Nishi, H., Satoh, M., Nagai, R., Kimura, A. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Biochem. Biophys. Res. Commun. 261: 332-339, 1999. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))
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别名
- SOD2
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背景
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Synonyms: Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, CASP3, CPP32
Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Background: SOD2(Superoxide Dismutase 2), also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH analysis, indicated that SOD2 is in the distal portion of 6q25. The SOD2 gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the human SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease process.
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分子量
- 25 kDa
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基因ID
- 6648
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UniProt
- P04179
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途径
- Sensory Perception of Sound, Transition Metal Ion Homeostasis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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