DAB2 抗体 (AA 89-770)
Quick Overview for DAB2 抗体 (AA 89-770) (ABIN7602613)
抗原
See all DAB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 89-770
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原理
- Anti-DAB2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-DAB2 Antibody Picoband® (ABIN7602613). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human DAB2 recombinant protein (Position: H89-A770).
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亚型
- IgG
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anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 1-770) antibody
DAB2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 31-130) antibodyDAB2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 743-770), (C-Term) antibodyDAB2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23472 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (pSer24) antibodyDAB2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 743-770) antibodyDAB2 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 1-770) antibodyDAB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D6 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 673-770) antibodyDAB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (C-Term) antibodyDAB2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (AA 624-650), (C-Term) antibodyDAB2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40861 unconjugated
anti-Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) (N-Term) antibodyDAB2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat, Monkey
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Albertsen, H. M., Smith, S. A., Melis, R., Williams, B., Holik, P., Stevens, J., White, R. Sequence, genomic structure, and chromosomal assignment of human DOC-2. Genomics 33: 207-213, 1996. 2. Eden, E. R., Sun, X.-M., Patel, D. D., Soutar, A. K. Adaptor protein Disabled-2 modulates low density lipoprotein receptor synthesis in fibroblasts from patients with autosomal recessive hypercholesterolaemia. Hum. Molec. Genet. 16: 2751-2759, 2007. 3. Hocevar, B. A., Smine, A., Xu, X.-X., Howe, P. H. The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J. 20: 2789-2801, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
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别名
- DAB2
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背景
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Synonyms: Regulator of telomere elongation helicase 1
Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Background: Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene. This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 95 kDa
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基因ID
- 1601
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UniProt
- P98082
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
抗原
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