GJB2 抗体 (AA 88-137)
Quick Overview for GJB2 抗体 (AA 88-137) (ABIN7602589)
抗原
See all GJB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 88-137
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原理
- Anti-GJB2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GJB2 Antibody Picoband® (ABIN7602589). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GJB2 recombinant protein (Position: A88-T137).
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亚型
- IgG
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anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (AA 99-131) antibody
GJB2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (C-Term) antibodyVerified GJB2 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (AA 1-226) antibodyGJB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C6 unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (Cytoplasmic Domain) antibodyGJB2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal CX-12H10 unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) antibodyGJB2 适用: 人, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (Internal Region) antibodyGJB2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (Internal Region) antibodyGJB2 适用: 人, 小鼠, 大鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (AA 85-134) antibodyGJB2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (N-Term) antibodyGJB2 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, beta 2, 26kDa (GJB2) (Middle Region) antibodyGJB2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Mignon, C., Fromaget, C., Mattei, M.-G., Gros, D., Yamasaki, H., Mesnil, M. : Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-q12 and mouse chromosome 14D1-E1 by in situ hybridization. Cytogenet. Cell Genet. 72: 185-186, 1996. 2. Djalilian, A. R., McGaughey, D., Patel, S., Seo, E. Y., Yang, C., Cheng, J., Tomic, M., Sinha, S., Ishida-Yamamoto, A., Segre, J. A. : Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J. Clin. Invest. 116: 1243-1253, 2006. 3. Abe, S., Kelley, P. M., Kimberling, W. J., Usami, S. : Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation. Am. J. Med. Genet. 103: 334-338, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- GJB2 (Gap Junction Protein, beta 2, 26kDa (GJB2))
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别名
- GJB2
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背景
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Synonyms: Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5, CDKN5
Tissue Specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.
Background: Connexin26(CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5 % identity with rat Cx26. connexin 26(GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene(GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.
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分子量
- 26 kDa
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基因ID
- 2706
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UniProt
- P29033
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途径
- Sensory Perception of Sound, Cell-Cell Junction Organization
抗原
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