Fibrillarin 抗体 (AA 77-138)
Quick Overview for Fibrillarin 抗体 (AA 77-138) (ABIN7602434)
抗原
See all Fibrillarin (FBL) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 77-138
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原理
- Anti-Fibrillarin/FBL Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Fibrillarin/FBL Antibody Picoband® (ABIN7602434). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Fibrillarin/FBL recombinant protein (Position: K77-N138).
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亚型
- IgG
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anti-Fibrillarin (FBL) antibody
FBL 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibrillarin (FBL) (AA 100-321) antibodyFBL 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibrillarin (FBL) antibodyFBL 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Fibrillarin (FBL) antibodyFBL 适用: 人 WB, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibrillarin (FBL) antibodyFBL 适用: Saccharomyces cerevisiae WB, IF 宿主: 小鼠 Monoclonal 38F3 unconjugated
anti-Fibrillarin (FBL) (AA 1-321) antibodyFBL 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G9-E4 unconjugated
anti-Fibrillarin (FBL) (N-Term) antibodyFBL 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibrillarin (FBL) (Internal Region) antibodyFBL 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Fibrillarin (FBL) (AA 61-110) antibodyFBL 适用: 人, 大鼠, 小鼠, 犬, Cow, 猴, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fibrillarin (FBL) (N-Term) antibodyFBL 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Monkey
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Aris, J. P., Blobel, G. cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc. Nat. Acad. Sci. 88: 931-935, 1991. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 7/9/2010. 3. Okano, Y., Steen, V. D., Medsger, T. A., Jr. Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis. Arthritis Rheum. 35: 95-100, 1992. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Fibrillarin (FBL)
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别名
- FBL
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背景
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Synonyms: IFNGR2 protein, Interferon gamma receptor 2, IFNGR2, mCG_11456
Tissue Specificity: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
Background: rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene. This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.
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分子量
- 37 kDa
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基因ID
- 2091
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UniProt
- P22087
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途径
- Ribonucleoside Biosynthetic Process
抗原
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