Desmoplakin 抗体 (AA 69-2195)
Quick Overview for Desmoplakin 抗体 (AA 69-2195) (ABIN7602296)
抗原
See all Desmoplakin (DSP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 69-2195
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原理
- Anti-Desmoplakin/DSP Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Desmoplakin/DSP Antibody Picoband® (ABIN7602296). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Desmoplakin/DSP recombinant protein (Position: N69-H2195).
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亚型
- IgG
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anti-Desmoplakin (DSP) (AA 2609-2822) antibody
DSP 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 1-100) antibodyDSP 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) antibodyDSP 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (Internal Region) antibodyVerified DSP 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Desmoplakin (DSP) (C-Term) antibodyDSP 适用: 人, 小鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoplakin (DSP) (AA 2750-2850) antibodyDSP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Choi HJ, Weis WI (2011). "Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain". J. Mol. Biol. 409 (5): 800-12. 2. Green KJ, Parry DA, Steinert PM, Virata ML, Wagner RM, Angst BD, Nilles LA (Feb 1990). "Structure of the human desmoplakins. Implications for function in the desmosomal plaque". The Journal of Biological Chemistry. 265 (5): 2603-12. 3. Jonkman MF, Pasmooij AM, Pasmans SG, van den Berg MP, Ter Horst HJ, Timmer A, Pas HH (Oct 2005). "Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa". American Journal of Human Genetics. 77 (4): 653-60. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Desmoplakin (DSP)
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别名
- DSP
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背景
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Synonyms: Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP
Tissue Specificity: Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.
Background: Desmoplakin is a protein in humans that is encoded by the DSP gene. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.
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分子量
- 250 kDa
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基因ID
- 1832
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UniProt
- P15924
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途径
- Cell-Cell Junction Organization
抗原
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