FLT3 抗体 (AA 66-993)
Quick Overview for FLT3 抗体 (AA 66-993) (ABIN7602257)
抗原
See all FLT3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 66-993
-
原理
- Anti-CD135/FLT3 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-/FLT3 Antibody Picoband® (ABIN7602257). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human CD135/FLT3 recombinant protein (Position: A66-S993).
-
亚型
- IgG
-
-
anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 930-991) antibody
FLT3 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 7B7C3 unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 62-295) antibodyFLT3 适用: 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) antibodyFLT3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 334-543) antibodyFLT3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 335-544) antibodyFLT3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 33-64) antibodyFLT3 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) (C-Term) antibodyFLT3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fms-Related tyrosine Kinase 3 (FLT3) antibody (FITC)FLT3 适用: 人 FACS 宿主: 小鼠 Monoclonal BV10A4 FITC
anti-Fms-Related tyrosine Kinase 3 (FLT3) antibody (PE)FLT3 适用: 人 FACS 宿主: 小鼠 Monoclonal BV10A4 PE
anti-Fms-Related tyrosine Kinase 3 (FLT3) (AA 650-750) antibodyFLT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Abu-Duhier, F. M., Goodeve, A. C., Wilson, G. A., Care, R. S., Peake, I. R., Reilly, J. T. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Brit. J. Haemat. 113: 983-988, 2001. 2. Abu-Duhier, F. M., Goodeve, A. C., Wilson, G. A., Gari, M. A., Peake, I. R., Rees, D. C., Vanderberghe, E. A., Winship, P. R., Reilly, J. T. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Brit. J. Haemat. 111: 190-195, 2000. 3. Ansari-Lari, M. A., Yang, C.-F., Tinawi-Aljundi, R., Cooper, L., Long, P., Allan, R. H., Borowitz, M. J., Berg, K. D., Murphy, K. M. FLT3 mutations in myeloid sarcoma. Brit. J. Haemat. 126: 785-791, 2004. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
-
别名
- FLT3
-
背景
-
Synonyms: Receptor-type tyrosine-protein kinase FLT3, 2.7.10.1, FL cytokine receptor, Fetal liver kinase 2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Tyrosine-protein kinase receptor flk-2, CD135, Flt3, Flk-2, Flt-3,
Tissue Specificity: Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis.
Background: Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
-
分子量
- 160 kDa
-
基因ID
- 2322
-
UniProt
- P36888
-
途径
- RTK signaling
抗原
-
