FAP 抗体 (AA 65-580)
Quick Overview for FAP 抗体 (AA 65-580) (ABIN7602234)
抗原
See all FAP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 65-580
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原理
- Anti-Fibroblast activation protein, alpha/FAP Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Fibroblast activation protein, alpha/FAP Antibody Picoband® (ABIN7602234). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Fibroblast activation protein, alpha/FAP recombinant protein (Position: Q65-Q580).
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亚型
- IgG
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anti-Fibroblast Activation Protein, alpha (FAP) (AA 525-624) antibody
FAP 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1E5 unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 26-264) antibodyFAP 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1H12F2 unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 542-761) antibodyFAP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 311-410) antibodyFAP 适用: 人, 小鼠, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 523-760) antibodyFAP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 523-760) antibodyFAP 适用: 人 WB 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 542-761) antibodyFAP 适用: 小鼠 WB, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (Internal Region) antibodyFAP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) antibodyFAP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Activation Protein, alpha (FAP) (AA 15-41), (N-Term) antibodyFAP 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB40867 unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Goldstein, L. A., Ghersi, G., Pineiro-Sanchez, M. L., Salamone, M., Yeh, Y., Flessate, D., Chen, W.-T. Molecular cloning of seprase: a serine integral membrane protease from human melanoma. Biochim. Biophys. Acta 1361: 11-19, 1997. 2. Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., Fearon, D. T. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 330: 827-830, 2010. 3. Mathew, S., Scanlan, M. J., Mohan Raj, B. K., Murty, V. V. V. S., Garin-Chesa, P., Old, L. J., Rettig, W. J., Chaganti, R. S. K. The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23. Genomics 25: 335-337, 1995. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- FAP (Fibroblast Activation Protein, alpha (FAP))
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别名
- FAP
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背景
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Synonyms: Prolyl endopeptidase FAP
Tissue Specificity: Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
Background: Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 97 kDa
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基因ID
- 2191
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UniProt
- Q12884
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途径
- Tube Formation
抗原
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