SOX18 抗体 (AA 63-362)
Quick Overview for SOX18 抗体 (AA 63-362) (ABIN7602205)
抗原
See all SOX18 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 63-362
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原理
- Anti-SOX18 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SOX18 Antibody Picoband® (ABIN7602205). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SOX18 recombinant protein (Position: E63-E362).
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亚型
- IgG
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anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (Middle Region) antibody
SOX18 适用: 人, 小鼠, 大鼠, Cow, 豚鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 63-150) antibodySOX18 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 153-377) antibodySOX18 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 271-320) antibodySOX18 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, Pig, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 63-150) antibodySOX18 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 192-241) antibodySOX18 适用: 人, 小鼠, 大鼠, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 1-100) antibodySOX18 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) antibodySOX18 适用: 人 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Monkey, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Azuma, T., Seki, N., Yoshikawa, T., Saito, T., Masuho, Y., Muramatsu, M. cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18. J. Hum. Genet. 45: 192-195, 2000. 2. Devriendt, K., Vikkula, M., Irrthum, A., Mattjijs, G., Mertens, A., Fryns, J.-P. Autosomal recessive alopecia and lymphedema. (Abstract) Genet. Counsel. 13: 74-75, 2002. 3. Downes, M., Francois, M., Ferguson, C., Parton, R. G., Koopman, P. Vascular defects in the mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum. Molec. Genet. 18: 2839-2850, 2009. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))
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别名
- SOX18
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背景
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Synonyms: Ran-specific GTPase-activating protein,Ran-binding protein 1,RanBP1,RANBP1,
Tissue Specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Background: Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
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分子量
- 41 kDa
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基因ID
- 54345
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UniProt
- P35713
抗原
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