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MUS81 抗体 (AA 6-545)

MUS81 适用: 人, 大鼠 ELISA, WB, FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7602139
发货至: 中国
  • 抗原 See all MUS81 抗体
    MUS81 (MUS81 Endonuclease Homolog (MUS81))
    抗原表位
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 6-545
    适用
    • 15
    • 6
    • 4
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 14
    • 1
    克隆类型
    • 15
    多克隆
    标记
    • 11
    • 2
    • 1
    • 1
    This MUS81 antibody is un-conjugated
    应用范围
    • 8
    • 7
    • 5
    • 4
    • 1
    ELISA, Western Blotting (WB), Flow Cytometry (FACS)
    原理
    Anti-MUS81 Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins.
    产品特性
    Anti-MUS81 Antibody Picoband® (ABIN7602139). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human MUS81 recombinant protein (Position: R6-C545).
    亚型
    IgG
    Top Product
    Discover our top product MUS81 Primary Antibody
  • 应用备注
    Western blot, 0.25-0.5 μg/mL, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Chen, X.-B., Melchionna, R., Denis, C.-M., Gaillard, P.-H. L., Blasina, A., Van de Weyer, I., Boddy, M. N., Russell, P., Vialard, J., McGowan, C. H. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Molec. Cell 8: 1117-1127, 2001. 2. Ciccia, A., Constantinou, A., West, S. C. Identification and characterization of the human Mus81-Eme1 endonuclease. J. Biol. Chem. 278: 25172-25178, 2003. 3. Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N., de Winter, J. P., Wang, W., West, S. C. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Molec. Cell 25: 331-343, 2007.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    储存条件
    4 °C,-20 °C
    储存方法
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原
    MUS81 (MUS81 Endonuclease Homolog (MUS81))
    别名
    MUS81 (MUS81 产品)
    背景

    Synonyms: Lipopolysaccharide-binding protein, LBP, Lbp,

    Tissue Specificity: Detected in blood serum (at protein level).

    Background: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

    分子量
    70 kDa
    基因ID
    80198
    途径
    DNA Damage Repair
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