MUS81 抗体 (AA 6-545)
Quick Overview for MUS81 抗体 (AA 6-545) (ABIN7602139)
抗原
See all MUS81 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-545
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原理
- Anti-MUS81 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MUS81 Antibody Picoband® (ABIN7602139). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MUS81 recombinant protein (Position: R6-C545).
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亚型
- IgG
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anti-MUS81 Endonuclease Homolog (MUS81) (AA 82-265) antibody
MUS81 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) (AA 1-350) antibodyMUS81 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) antibodyMUS81 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) (AA 1-551) antibodyMUS81 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) (C-Term) antibodyMUS81 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) (AA 207-256) antibodyMUS81 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) (AA 276-325) antibodyMUS81 适用: 人, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-MUS81 Endonuclease Homolog (MUS81) (C-Term) antibodyMUS81 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chen, X.-B., Melchionna, R., Denis, C.-M., Gaillard, P.-H. L., Blasina, A., Van de Weyer, I., Boddy, M. N., Russell, P., Vialard, J., McGowan, C. H. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Molec. Cell 8: 1117-1127, 2001. 2. Ciccia, A., Constantinou, A., West, S. C. Identification and characterization of the human Mus81-Eme1 endonuclease. J. Biol. Chem. 278: 25172-25178, 2003. 3. Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N., de Winter, J. P., Wang, W., West, S. C. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Molec. Cell 25: 331-343, 2007. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- MUS81 (MUS81 Endonuclease Homolog (MUS81))
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别名
- MUS81
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背景
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Synonyms: Lipopolysaccharide-binding protein, LBP, Lbp,
Tissue Specificity: Detected in blood serum (at protein level).
Background: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.
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分子量
- 70 kDa
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基因ID
- 80198
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途径
- DNA Damage Repair
抗原
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