PREX2 抗体 (AA 582-1094)
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- 抗原 See all PREX2 (DEPDC2) 抗体
- PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))
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抗原表位
- AA 582-1094
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PREX2 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB)
- 原理
- Anti-PREX2 Antibody Picoband®
- 交叉反应 （详细）
- No cross-reactivity with other proteins.
- 产品特性
- Anti-PREX2 Antibody Picoband® (ABIN7602086). Tested in ELISA, WB applications. This antibody reacts with Human, MouseThe brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human PREX2 recombinant protein (Position: D582-Q1094).
- 亚型
- IgG
- Top Product
- Discover our top product DEPDC2 Primary Antibody
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anti-DEP Domain Containing 2 (DEPDC2) (AA 1417-1592) antibody
DEPDC2 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (AA 1-979) antibodyDEPDC2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (N-Term) antibodyDEPDC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., Zhang, H., Zeid, R., and 36 others. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485: 502-506, 2012. 2. Donald, S., Hill, K., Lecureuil, C., Barnouin, R., Krugmann, S., Coadwell, W. J., Andrews, S. R., Walker, S. A., Hawkins, P. T., Stephens, L. R., Welch, H. C. E. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 572: 172-176, 2004. 3. Donald, S., Humby, T., Fyfe, I., Segonds-Pichon, A., Walker, S. A., Andrews, S. R., Coadwell, W. J., Emson, P., Wilkinson, L. S., Welch, H. C. E. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc. Nat. Acad. Sci. 105: 4483-4488, 2008. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- 抗原
- PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))
- 别名
- PREX2 (DEPDC2 产品)
- 背景
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Synonyms: Neurocan core protein, Chondroitin sulfate proteoglycan 3, NCAN, CSPG3, NEUR,
Tissue Specificity: Brain.
Background: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.
- 分子量
- 183 kDa
- 基因ID
- 80243
- UniProt
- Q70Z35
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